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Mitchell (Josh Duhamel) and Carter (Dan Fogler), life-long friends who have drifted apart, are on a road trip when their old pickup breaks down, leaving them stranded on an isolated desert road. Nobody can pick apart a man like his best friend, and as the relentless elements of the desert grind them down, they start to attack each other s life decisions with unwavering brutality. As they question who they are and who they could have been, their agitation leads to physical confrontation and ultimately knife-wielding madness, and what begins as an inconvenience becomes a very real life or death struggle